Bailor

Shizuo Akira, M.D., Ph.D.

WPI Immunology Frontier Research Center, Osaka University,

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Distribution for a fee Guide Knockout mice

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OrientalBioService

TLR family Knockout mice

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photo:mouse(white)-OrientalBioServicephoto:Cells-OrientalBioServiceテキスト ボックス: Natural immunomechanism by TLR

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It is the knockout mice which made the indispensable molecule suffer a loss to the signal transfer to immune cells (neor and substitution).

> Download Pamphlet (PDF)   > TLR

In stock

Strain

Background

Reference

C57BL/6

BALB/c

129×B6

Live

Embryo

MEF

Live

Embryo

Embryo

TLR & adaptor

MyD88 KO

 

Adachi, O. et al., 1998. Immunity.

9: 143-150.

TLR1 KO

 

 

 

 

Takeuchi, O. et al., 2002. J Immunol. 169: 10-14.

TLR2 KO

 

Takeuchi, O. et al., 1999. Immunity.

11: 443-451.

TLR3 KO

 

 

Yamamoto, M. et al., 2003. Science. 301: 640-643.

TLR4 KO

 

Hoshino, K. et al., 1999. J Immunol. 162: 3749-3752.

TLR5 KO

 

 

 

 

Uematsu, S. et al., 2006. Nat Immunol. 7: 868-874.

TLR6 KO

 

 

 

 

Takeuchi, O. et al., 2001. Int Immunol. 13: 933-940.

TLR7 KO

 

 

 

Hemmi, H. et al., 2002. Nat Immunol.

3: 196-200.

TLR9 KO

 

 

 

Hemmi, H. et al., 2000. Nature.

408: 740-745.

TLR2/4

 double KO

 

 

 

 

TLR7/9

 double KO

 

 

 

 

TLR2/4/9

 Triple KO

 

 

 

 

TRIF KO

 

 

 

 

Yamamoto, M. et al., 2003. Science. 301: 640-643.

Myd88/TRIF

Double KO

 

 

 

 

TRAM KO

 

 

 

 

Yamamoto, M. et al., 2003. Nat Immunol. 7: 1144-1150.

TIRAP KO

 

 

 

Yamamoto, M. et al., 2002. Nature. 420: 324-329.

RLR family

RIG-I KO

 

 

 

 

 

Hiroki, K. et al., 2005. Immunity. 23: 19-28.

MDA5 KO

 

 

 

 

 

Hiroki, K. et al., 2006. Nature. 441: 101-105.

LGP2 KO

 

 

 

 

 

Takeshi, S. et al., 2010.PNAS. 107: 1512-1517.

Transcription & regulator

Floxed Stat3

 KO

 

 

 

 

 

Takeda, K. et al., 1998. J Immunol. 161: 4652-4660.

Takeda, K. et al., 1999. Immunity. 10: 39-49.

Others

mPGES1

 

 

 

 

Uematsu,S.et al.,2002. J Immunol.

1685811-5816

*1 129/SvJ x C57Bl/6 Mixed.

(Only RIG-I KO will be 129xB6xICR.)

*2 Available on production orders for MEF cell.

     MEF(Mouse Embryonic Fibroblast) cell.

 

If you wish to mouse individual of from frozen embryo, please contact us.