TLR Series KO mice | OrientalBioService,Inc

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Shizuo Akira, M.D., Ph.D.

WPI Immunology Frontier Research Center, Osaka University,

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Distribution for a fee Guide Knockout mouse

OrientalBioService

◆TLR family Knockout mouse

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Health & Husbandry Statement

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Microbiological　Monitoring Report

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TLR family KO mouse

EMU Mutant mouse

Transgenic Rat

Please refer to here for the Health Monitoring Item (Japanese).

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○（embryo）university or non-profit organization Only

Ｓｔｒａｉｎ	Background				Reference
	C57BL/6		BALB/c
	Live	Embrｙo	Live	Embrｙo
MyD88　KO	○	○	○		Adachi, O. et al., 1998. Immunity. 9: 143-150.
TLR1 KO	○	○			Takeuchi, O. et al., 2002. J Immunol. 169: 10-14.
TLR2 KO	○	○	○		Takeuchi, O. et al., 1999. Immunity. 11: 443-451.
TLR4 KO	○	○			Hoshino, K. et al., 1999. J　Immunol. 162: 3749-3752.
TLR6 KO	○	○	○		Takeuchi, O. et al., 2001. Int Immunol. 13: 933-940.
TLR7 KO	○	○	○		Hemmi, H. et al., 2002. Nat Immunol. 3: 196-200.
TLR9 KO	○	○	○		Hemmi, H. et al., 2000. Nature. 408: 740-745.
TLR2/4 double KO	○				Immunity. 1999 Oct; 11(4) :443-51. J Immunol. 1999 Apr 1;162(7) :3749-52
TLR7/9 double KO	○				Nat Immunol. 2002 Feb;3(2) :196-200 Nature. 2000 Dec 7;408(6813) :740-5